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问题：
[单选题]下列哪项是小儿肾病综合征最主要的病理生理改变
A、肾脏排钠障碍导致高度水肿
B、高血脂可引起系膜细胞增殖和系膜基质增加
C、低蛋白血症形成可导致高度水肿
D、脂蛋白分解代谢障碍所致高脂血症
E、因肾小球滤过膜的通透性增加导致大量蛋白尿
参考答案：
E
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