[单选题]环境流行病学的研究必须考虑哪种情况( )

A、已知暴露因素,研究健康效应
B、已知人群中健康已出现异常,寻找病因
C、因果均已清楚,研究剂量-反应关系
D、以上均考虑
E、以上均不考虑

参考答案： C

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